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CJNM / Volume 2  / Issue 1
CJNM Volume 2 issue 1

Issue 1 March 2022

25/03/2022
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Issue 1, Volume 2

Our first issue of 2022 has Dr Hilborn delivering an excellent review of powerful links between insulin resistance and PCOS. Dr Nelson eloquently takes us back in time to string together the history leading to tremendous misinformation in the realm of acid-alkaline balance, then goes on to provide a thorough overview of modern perspectives of an important and often overlooked topic. Dr Mudry brings the concept of environmental stewardship to light in the context of botanical medicine while showcasing berberine as both a wonderfully effective and sustainable medicine. Dr Fritz delivers a comprehensive review of clinical applications of hops, a medicine that has received considerable research attention in the past 15 years. And CJNM is again thrilled to deliver a world class human intervention trial...

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Dietary Acid Load: From Kimball C Atwood, the Father of Functional Food, to Contemporary Science

25/03/2022
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Issue 1

Abstract Much has been written about the “alkaline diet” in the lay press. Proponents suggest it is a cure-all for endless lists of human ailments. Critics suggest that since acid-base balance is so tightly regulated, the acidity or alkalinity of diet is, with only few exceptions, of little relevance to human health. This review explores early origins of the marketing of the acid-alkaline diet and reflect its rudimentary science off a more sophisticated, contemporary understanding of dietary acid load. As outlined here, the North American alkaline diet phenomenon was manufactured by grapefruit mogul and food faddist, Kimball C Atwood. The marketing techniques initiated by Atwood—using the trapping of science to promote a healthy idea to the masses—were highly lucrative and imitated by many other companies. However,...

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Insulin Resistance in Polycystic Ovary Syndrome (PCOS): Evaluation and Important Associations

24/03/2022
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Issue 1

Abstract PCOS is common, and as understanding evolves to recognize many diverse presentations, prevalence of PCOS continues to increase. There are clear associations of tremendous interest to the clinician between PCOS and an array of common patient complaints, and insulin resistance seems to play a key role in most such presentations. The gold-standard tool for assessing insulin sensitivity, the euglycemic-hyperinsulinemic clamp technique is reserved for research purposes and is not broadly available as a diagnostic test. This review will showcase associations between PCOS, insulin resistance, and several important common patient concerns. The review will also attempt to determine if an adequate alternative to the euglycemic-hyperinsulinemic clamp technique exists for accurate determination of insulin resistance in outpatient practice. Introduction The prevalence of polycystic ovarian syndrome (PCOS) is high. Insulin...

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Immunomodulatory and Anti-Inflammatory Actions of Berberine-Containing Herbs

24/03/2022
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Issue 1

Abstract Sustainability of commonly employed medicinal plants is becoming a global concern, heightened by shortages imposed during the current pandemic. Berberine-containing plants are found broadly in nature, present across several families of plants and potentially cultivated almost anywhere in the world. Research in berberine has exploded in recent years, leaving a well-developed body of good quality evidence demonstrating a wide array of important clinical outcomes across a broad spectrum of applications. This review will showcase important roles of berberine from both modern research and traditional herbal systems of medicine. The review will also raise important concepts relating to herbal medicine sustainability and demonstrate that berberine ranks very high when considering environmental stewardship while seeking safe and effective herbal medicines. Introduction With the prevalence of chronic disease and inflammation...

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Hops (Humulus lupulus): An Overview of Clinical Applications

24/03/2022
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Issue 1

Abstract Hops (Humulus lupulus) has been used for millennia in the brewing of beer, imparting flavour and aroma to the beverage, as well as improving shelf life. Interest in hops as a medicine, however, did not gain momentum until the early 1800s. Modern investigation has revealed an array of constituents of interest, having impact across a broad number of important clinical indications. The prenylflavanoid xanthohumulol is a noted antioxidant and is receiving extensive preclinical interest as an anti-tumour agent. This molecule is capable of undergoing transformation by gut microbes giving rise to 8-prenylnaringenin, a powerful phytoestrogen heralded as delivering hops’ impact to symptoms of menopause. The bitter acids of hops are principally credited with delivering effects related to sedation. The paper introduces clinicians to a versatile...

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Effect of Consumption of Functional Foods Consisting of High-Oleic Canola Oil, Docosahexaenoic Acid and Barley β-glucan on Plasma Lipids, Blood Pressure, and Framingham Risk Score in Human Population with Metabolic Syndrome: A Randomized Crossover Trial

20/03/2022
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Abstract Functional foods such as high-oleic canola oil, omega-3 oils and barley β-glucan, have individually been shown to improve blood lipid profiles. The objective of the study was to test the synergistic effect of consuming a combination of novel foods with functional ingredients on blood lipid profile, blood pressure, and the Framingham risk score. A randomized single-blinded free-living crossover study design was used. The study involved thirty-five participants and consisted of four intervention phases, (1) muffins and cookies containing all-purpose flour and 50g/day of a blend of sunflower oil, safflower oil, and butter as a control oil; (2) barley flour with 4.36g/day of HMW-BBG and 50g/day of a blend of sunflower oil, safflower oil, and butter as control oil; (3) all-purpose flour, and 50g/day HOCO-DHA (85:15...

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