Vitamin D: Focus on Immune Modulation
Abstract Vitamin D supplementation is not strictly for healthy bone metabolism. There is a significant expression of vitamin D receptors (VDRs) in specific target cells and tissues. Vitamin D deficiency is very common around the world, being affected by latitude/winter season, melanin production, pharmaceutical side effects, obesity, and fat malabsorption disorders. Deficient serum vitamin D levels modulate VDR expression which influences expression of downstream genes and induces protein cascades in different tissues to elicit disease symptoms. The common theme in all of the studies reviewed is the role vitamin D plays in the immune response. Vitamin D deficiency has been implicated in not only immune related conditions, but chronic medical conditions as well. While the mechanism of action of vitamin D in these conditions has not...