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Dietary Acid Load: From Kimball C Atwood, the Father of Functional Food, to Contemporary Science

Abstract Much has been written about the “alkaline diet” in the lay press. Proponents suggest it is a cure-all for endless lists of human ailments. Critics suggest that since acid-base balance is so tightly regulated, the acidity or alkalinity of diet is, with only few exceptions, of little relevance to human health. This review explores early origins of the marketing of the acid-alkaline diet and reflect its rudimentary science off a more sophisticated, contemporary understanding of dietary acid load. As outlined here, the North American alkaline diet phenomenon was manufactured by grapefruit mogul and food faddist, Kimball C Atwood. The marketing techniques initiated by Atwood—using the trapping of science to promote a healthy idea to the masses—were highly lucrative and imitated by many other companies. However,...

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Insulin Resistance in Polycystic Ovary Syndrome (PCOS): Evaluation and Important Associations

Abstract PCOS is common, and as understanding evolves to recognize many diverse presentations, prevalence of PCOS continues to increase. There are clear associations of tremendous interest to the clinician between PCOS and an array of common patient complaints, and insulin resistance seems to play a key role in most such presentations. The gold-standard tool for assessing insulin sensitivity, the euglycemic-hyperinsulinemic clamp technique is reserved for research purposes and is not broadly available as a diagnostic test. This review will showcase associations between PCOS, insulin resistance, and several important common patient concerns. The review will also attempt to determine if an adequate alternative to the euglycemic-hyperinsulinemic clamp technique exists for accurate determination of insulin resistance in outpatient practice. Introduction The prevalence of polycystic ovarian syndrome (PCOS) is high. Insulin...

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Immunomodulatory and Anti-Inflammatory Actions of Berberine-Containing Herbs

Abstract Sustainability of commonly employed medicinal plants is becoming a global concern, heightened by shortages imposed during the current pandemic. Berberine-containing plants are found broadly in nature, present across several families of plants and potentially cultivated almost anywhere in the world. Research in berberine has exploded in recent years, leaving a well-developed body of good quality evidence demonstrating a wide array of important clinical outcomes across a broad spectrum of applications. This review will showcase important roles of berberine from both modern research and traditional herbal systems of medicine. The review will also raise important concepts relating to herbal medicine sustainability and demonstrate that berberine ranks very high when considering environmental stewardship while seeking safe and effective herbal medicines. Introduction With the prevalence of chronic disease and inflammation...

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Hops (Humulus lupulus): An Overview of Clinical Applications

Abstract Hops (Humulus lupulus) has been used for millennia in the brewing of beer, imparting flavour and aroma to the beverage, as well as improving shelf life. Interest in hops as a medicine, however, did not gain momentum until the early 1800s. Modern investigation has revealed an array of constituents of interest, having impact across a broad number of important clinical indications. The prenylflavanoid xanthohumulol is a noted antioxidant and is receiving extensive preclinical interest as an anti-tumour agent. This molecule is capable of undergoing transformation by gut microbes giving rise to 8-prenylnaringenin, a powerful phytoestrogen heralded as delivering hops’ impact to symptoms of menopause. The bitter acids of hops are principally credited with delivering effects related to sedation. The paper introduces clinicians to a versatile...

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Effect of Consumption of Functional Foods Consisting of High-Oleic Canola Oil, Docosahexaenoic Acid and Barley β-glucan on Plasma Lipids, Blood Pressure, and Framingham Risk Score in Human Population with Metabolic Syndrome: A Randomized Crossover Trial

Abstract Functional foods such as high-oleic canola oil, omega-3 oils and barley β-glucan, have individually been shown to improve blood lipid profiles. The objective of the study was to test the synergistic effect of consuming a combination of novel foods with functional ingredients on blood lipid profile, blood pressure, and the Framingham risk score. A randomized single-blinded free-living crossover study design was used. The study involved thirty-five participants and consisted of four intervention phases, (1) muffins and cookies containing all-purpose flour and 50g/day of a blend of sunflower oil, safflower oil, and butter as a control oil; (2) barley flour with 4.36g/day of HMW-BBG and 50g/day of a blend of sunflower oil, safflower oil, and butter as control oil; (3) all-purpose flour, and 50g/day HOCO-DHA (85:15...

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Issue 3 December 2021

The lineup of review articles is must-read stuff! Neil McKinney does a tremendous job of showcasing the basis for consideration of cannabidiol in cancer care. Odessa Gill and Erin Valente introduce a simple, non-invasive liver scan with impressive sensitivity and specificity for detecting liver fibrosis. The test can easily be rolled out in outpatient integrative healthcare practice. Tori Hudson and Sarah Tindall deliver an excellent review of ginger with a focus on women’s health. Several applications backed with human level evidence are certainly news to me! Daniella Perri delivers an eloquent and detailed review of mechanisms through which vitamin D achieves outcomes of immunomodulation. I am privileged to provide a review establishing safety of low- hyperforin extracts of St John’s wort with all classes of...

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Cannabidiol (CBD) in Cancer Care

Abstract Cannabidiol (CBD) is a medically active but non-psychotropic constituent of Cannabis spp. It is a modulator of the intrinsic endocannbinoid system, which has significant regulatory and homeostatic functions in several important systems in the human body. Of particular interest is the impact CBD may have on the immune system, inflammation, anxiety, pain, and neuronal injury. Emerging evidence suggests these properties of CBD may be a valuable adjunct to the standard of care in oncology. It may reduce harm from chemotherapy and radiation therapy with no reduction in therapeutic efficacy. It may moderate graft-versus-host disease after stem cell transplants and moderate the formation of cancer stem cells involved in cancer progression, spread, treatment resistance, and relapses. CBD may even directly suppress cancer cells via mitochondrial-dependent apoptosis...

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FibroScan as a Simple Non-Invasive Screening Tool in Predicting Fibrosis in Non-Alcoholic Fatty Liver Disease Patients

Abstract The use of FibroScan in a clinical setting has been well established. Numerous studies demonstrate the efficacy of FibroScan as a screening tool in non-alcoholic fatty liver disease (NAFLD) patients. This non-invasive device is a valuable tool in a naturopathic practice to help identify NAFLD patients and those with suspected liver disease. The article will showcase human evidence assessing sensitivity and specificity of this important clinical tool. It is hoped the paper encourages more naturopathic doctors to make this simple, safe, and cost-effective tool available to their patients. Introduction Non-alcoholic fatty liver disease (NAFLD) is a condition in which there is an accumulation of excess fat in hepatocytes in people who consume little or no alcohol. The prevalence of NAFLD is estimated to be 20 to 40%...

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Ginger in Women’s Health Care: Gynecology and Primary Care

Abstract The well-known herb ginger, or Zingiber officinale, has been used for medicinal and culinary purposes for thousands of years throughout the world. Traditionally, ginger has been used to address a variety of ailments including nausea, vomiting, colds, arthritis, and headaches, among others. Although it is not often thought of as an herb for women’s health, there are a myriad of clinical uses for ginger to support medical conditions that are women-only as well as some that tend to impact women more often. This article seeks to highlight some of these uses of ginger beyond its antiemetic action by also discussing applications of ginger for dysmenorrhea, heavy menses, migraines, IBS, osteoarthritis, and exercise induced myalgia. Introduction Ginger root (Zingiber officinal Roscoe) is widely known and used as a...

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Vitamin D: Focus on Immune Modulation

Abstract Vitamin D supplementation is not strictly for healthy bone metabolism. There is a significant expression of vitamin D receptors (VDRs) in specific target cells and tissues. Vitamin D deficiency is very common around the world, being affected by latitude/winter season, melanin production, pharmaceutical side effects, obesity, and fat malabsorption disorders. Deficient serum vitamin D levels modulate VDR expression which influences expression of downstream genes and induces protein cascades in different tissues to elicit disease symptoms. The common theme in all of the studies reviewed is the role vitamin D plays in the immune response. Vitamin D deficiency has been implicated in not only immune related conditions, but chronic medical conditions as well. While the mechanism of action of vitamin D in these conditions has not...

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